Kajian Data Menunjukkan Cabaran Dalam Diet Mediterranean Ketogenik Untuk Penyakit Parkinson

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Dietary Strategies for Parkinson’s Patients: A Study Overview
Silke Cresswell-Appel, MD, recently shared findings from a fascinating study on dietary approaches for managing Parkinson’s disease (PD) during the 2024 International Congress of Parkinson’s Disease and Movement Disorders in Philadelphia.
The study (NCT05469997) involved 50 participants who tested two different diets over 8-week phases: one was a high-fat, low-carb Mediterranean diet (MEDI-KD), and the other was a standard Mediterranean diet enriched with medium-chain triglycerides (MCT). Researchers were keen to explore how these diets might help since both the ketogenic and Mediterranean diets have shown potential benefits for PD patients.
By the end of the study, nearly all participants (45 out of 48) who attended the initial visit started their assigned diet. Most patients loved the new dietary guidance, enjoyed learning about Mediterranean cuisine, and started being more mindful of what they ate. However, some participants struggled with the restrictions of the ketogenic diet, which made socializing tricky, and reported gastrointestinal side effects from MCT oil.
Throughout the trial, a handful of participants (6 in total) decided to drop out for various reasons. For instance, while some cited social limitations and financial constraints, others stopped due to increased symptoms like tremors or digestive issues.
Interestingly, the study measured ketone levels in participants, noting that the average blood ketone levels during the MEDI-KD were about 0.42 mM, while the MEDI-MCT phase showed lower levels at around 0.27 mM. This is particularly intriguing as it can inform us about how dietary shifts might impact metabolism and energy levels in PD patients.
Parkinson’s disease is the second most common neurodegenerative condition and can lead to serious motor and non-motor impairments, impacting everything from daily activities to mental health. Levodopa remains the go-to medication, but there’s a growing interest in adjunctive treatments like dietary interventions, which could help lessen side effects.
A prior pilot study highlighted the promise of low-carb diets in alleviating PD symptoms. In that research, seven patients followed a ketogenic diet for 24 weeks, which included tailored meal plans. Afterward, they reported significant improvements in cognitive function, mood, and overall well-being.
Overall, it’s clear that food may play a bigger role in managing Parkinson’s than we previously thought. It’s exciting to see ongoing research in this area, providing new hope for patients and their families.
For more updates from MDS 2024, check out our coverage!
References:
Tosefsky K, Wang Y, Kuan A, et al. Interim analysis of the feasibility of Mediterranean-ketogenic dietary interventions in Parkinson’s disease. Presented at: 2024 MDS Congress; September 27-October 1; Philadelphia, PA. ABSTRACT 501 Tidman MM, White DR, White TA. Impact of a keto diet on symptoms of Parkinson’s disease, biomarkers, depression, anxiety, and quality of life: a longitudinal study. Neurodegenerative Disease Management. Published online June 13, 2024. doi:10.1080/17582024.2024.2352394

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