Natural Compound Fight Covid 19

---

It’s frustrating to hear when a covid + patient gets sent home with very little instruction on what they can to help themselves.
A #SARS-CoV-2 infection can be deadly because of its ability to stimulate a part of the #innateimmune response called the #inflammasome.
This results in the release of pro-#inflammatory cytokines, leading to cytokine storm and severe, sometimes irreversible, damage to #respiratory epithelium.
The SARS-CoV-2 virus has been shown to activate the NLRP3 inflammasome specifically.
A 2016 review article titled “Natural compounds as regulators of NLRP3 inflammasome-mediated IL-beta production” notes that “#resveratrol, #curcumin, #EGCG [epigallocatechin gallate], and #quercetin are potent inhibitors of NLRP3 inflammasome-mediated IL-1beta production, typically acting at more than one element of the involved pathways.”
However, it should be noted that these polyphenols have an even much broader biological effect, as they influence a variety of pathways.
For example, these polyphenols modulate NF-kB upregulation, which is useful to counteract the #COVID-19 ’hyper-inflammation.’
A preprint released on March 23, 2020, identified the ability of plant bioactive compounds to inhibit the COVID-19 main protease (Mpro), which contributes to #viralreplication.
There is much excitement surrounding the recent identification of Mpro, and it is a current potential pharmaceutical target.
Kaempferol, quercetin, luteolin-7-glucoside, demethoxycurcumin, naringenin, apigenin-7glucoside, oleuropein, curcumin, catechin, and epicatechin-gallate were the natural compounds that appeared to have the best potential to act as COVID-19 Mpro inhibitors.
Though further research is necessary to prove efficacy, this study provides the biologic plausibility and mechanistic support (SARS-CoV-2 protease inhibition) to justify their use.
For these reasons, the compounds listed in this image, at standard dosages, may help to prevent activation of the NLRP3 inflammasome, decrease NF-kB activation, and to potentially inhibit SARS-CoV-2 replication.
There are approx 155 peer reviewed articles that also to support this post.

---